Cyberspace has transformed the daily lives of people for the better. The rush to adopt cyberspace, however, has exposed its fragility and vulnerabilities: corporations, agencies, national infrastructure and individuals have been victims of cyber-attacks. In December 2011, the National Science and Technology Council (NSTC) with the cooperation of NSF issued a broad, coordinated Federal strategic plan for cybersecurity research and development to "change the game," minimize the misuses of cyber technology, bolster education and training in cybersecurity, establish a science of cybersecurity, and transition promising cybersecurity research into practice. This challenge requires a dedicated approach to research, development, and education that leverages the disciplines of mathematics and statistics, the social sciences, and engineering together with the computing, communications and information sciences. The Secure and Trustworthy Cyberspace (SaTC) program welcomes proposals that address Cybersecurity from a Trustworthy Computing Systems (TWC) perspective and/or a Social, Behavioral and Economic Sciences (SBE) perspective, or from the Secure, Trustworthy, Assured and Resilient Semiconductors and Systems (STARSS) perspective (see “Perspectives” below). In addition, we welcome proposals that integrate research addressing all of these perspectives (see below). Proposals may be submitted in one of the following three categories (plus Cybersecurity Education; see below): 1) Small projects: up to $500,000 in total budget, with durations of up to three years; 2) Medium projects: $500,001 to $1,200,000 in total budget, with durations of up to four years; 3) Large projects: $1,200,001 to $3,000,000 in total budget, with durations of up to five years.