This letter is to alert all basic social and behavioral science research communities of the National Science Foundation's interest in receipt of proposals that will enable a better understanding of the contributing factors, causes, and consequences of violence perpetrated by and against youth. This will advance the Foundation's goal to provide scientific evidence in support of important social issues. The interest spans both disciplinary and interdisciplinary research. Research responsive to this Dear Colleague Letter would advance the basic theories and methods to improve our understanding of the contributors to youth violence and to its reduction. The Foundation is especially interested in research relating to destructive violence as opposed to harm as a regrettable byproduct of other experiences or activities (e.g., contact sports).