Autism Speaks is accepting Letters of Intent for "out of the box" autism research projects that open new avenues to understanding the causes, diagnosis, subtyping, prevention, treatment, and cure of autism spectrum disorders. Grants of up to $100,000 will be awarded to support small investigator-initiated high-risk/high-impact projects that are potentially transformative and/or aim to overcome significant roadblocks in autism research within a twelve-month period. In particular Autism Speaks is seeking projects that may be too risky for regular research mechanisms. Funding is restricted to projects that identify risk factors for ASD that can lead to prevention and improved diagnosis and treatment; lower the age at which ASD is detected and improve access to early intervention for children with ASD; enhance quality of and access to medical care for individuals with ASD; promote the development of safe, effective interventions and medicines to reduce core and associated symptoms of ASD throughout an individual's lifespan; and improve the health and outcomes of adults with ASD from a lifetime perspective. Due: Rolling Deadline.