The sponsor invites applications to support research on the treatment of individuals with co-occurring alcohol use disorders and depression/anxiety. Anxiety disorders include generalized anxiety disorder, social phobia, and posttraumatic stress disorder. The scope of interest includes innovative pharmacological and behavioral treatments based on biological, psychological, behavioral, and social/cultural models of etiology and treatment of comorbid alcohol use disorders and depression/anxiety. In addition, this FOA accepts Comparative and Effectiveness Research applications which compare two or more different existing treatments in this comorbid population. This FOA is limited to depression and anxiety because of the high prevalence of these psychiatric disorders in individuals with alcohol use disorders. Due: The deadlines for receipt of standard R01 applications under this announcement are: February 16, June 16, and October 16 annually.